I think that one game really has nothing to do with the other. Obviously a bit of Prototype's potential PS3 sales got swallowed by releasing a week later than Infamous. However, the 360 version should sell more than Infamous because it's marketed to a US/EU audience and there are simply more 360's.
Regarding Infamous' sales on it's own merits though, I think it just stems from Sony's inability to find games to publish that really entice a larger portion of the userbase. Everything seems to do relatively well, and are decently successful, but they can't seem to reach beyond the 2-3 million mark for the most advertised, critically loved titles. The only two titles to pull in some really impressive sales are Motorstorm and Resistance, both of which are thought of more as flukes because of a lack of titles at the time to purchase, since both of their sequels bombed spectacularly in comparison. Sony just doesn't seem to be able to find a title or two (outside of GT of course) that captures a larger portion of the userbase, instead of that smaller segment of around 2 million that loves buying Sony published titles.








