Going by North American sales only. I didn't exclude handheld games because that's not right.
1. Super Mario Galaxy (wii)
2. Mario and Sonic at the Olympic Games (wii)
3. Guitar Hero 3 (PS2)
4. Mario and Sonic at the Olympic Games (DS)
5. Guitar Hero 3 (Wii)
6. Call of Duty 4 (360)
7. Halo 3 (360)
8. Guitar Hero 3 (360)
9. Madden NFL 2008 (PS2)
10. The Legend of Zelda: Phantom Hourglass (DS)
Lots of big games left out: Mass Effect, Rock Band, Assassin's Creed. Man it's going to be huge this holiday.