Games to play with GF/friends:
Rayman Raving Rabbids
Warioware Smooth Moves
Wii Sports :)
Games to play alone:
Zelda: Twilight Princess
Resident Evil 4
Godfather: Black Hand Edition
Other games i've heard are great:
Metroid Prime 3
Super Paper Mario
Near-future releases i'm waiting for(in order of anticipation):
Zack and Wiki
Super Mario Galaxy
Super Smash Brothers Brawl
No More Heroes
Rayman RR 2
.