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Stats87 said:

I think it also added the letters "R" and "P"

So we now have 5, E, 3, R, P and Big Boss.


Maybe it means MGS5 = PRE 3 (as in taking place for MGS 3)

 

That goes against the story of MGS3... notice the Eye Patch in the flashing pick of BigBoss....When was BigBoss shot in the Eye?



4 ≈ One