I hate Metroid prime 3 Corruption and other games that suck for lefties.

[Broncos724]

I'm left-handed, I've never had an issue aiming with my right hand, what I do is either have the Wiimote stabilized by putting the bottom of it on my chest or on a couch cushion. I can see how it would be hard to aim if you're holding the Wiimote up in the air and not stabilized against something.