I can't wait for Nintendo's E3 Conference either 
I think this year there will be at least one major announcement concerning the Wii. Particulary I hope for the first footage of the new Legend of Zelda. A new Metroid would be awesome as well and after the ending of the last one, I am pretty sure the Metroid Prime Series might continue in some way.
I believe that there is also a possibility that they have something up their sleves nobody thinks of at first...maybe a new Star Fox, Earthbound, Pilotwings or an old school Donkey Kong Country? All of the four would be awesome and I guess many, many gamers around the world would die to see such a game on the Wii.
Well, but of course it might happen that Nintendo's E3 performance is as dissapointing as the last one. But to be honest, I don't think so: looking at the current situation (thekitchensink pointet the most important points out), they have to act or they might lose their momentum.
So let's all hope the best. And I'm damn sure Big N won't let us down this year 
