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Having used all 3 methods

Wiimote = 9 (point and shoot - fast, natural, and very accurate)

Mouse = 8 (moving hand and shooting - fast, not quite as natural, but mostly accurate)

Pad = 5 (moving thumbs and shooting - can be quick, but clumsy, and less accurate)

Saying this though if someone spends a lot of time on anyone of those controls they will get quite good. But most people are so used to a mouse that at some level it will be better than anything else a person uses