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I definitely say The Sims!

Want to know why? Because Mario has made more than 200 (!) games and sold about 200 million copies.

The Sims? Two games and over 100 million already. Mario owned.  I believe everyone knows of The Sims franchise, and once The Sims 3 is released, I think we should expect 150 million + in sales regarding the series!

Also, Pokémon may be an alternative, but that's up to you.

What do you think about these, and what, in your opinion, should generally be considered as the most successful, prosperous, flourishing, biggest in the game industry?

I have made my choice, and declare Mario owned by the reason I above described.