Well, many people were surprised to find out that Bioshock runs smoothly on their PC's which don't have high-end graphics cards. It even runs on my other PC, with outdated radeon 9800pro (i had to apply the shader 2.0 mod)
If wii can have similar performance running at 480p as 9800Pro running at, let's say, 1024x768, then it's more than a viable option to port Bioshock to wii. Altho i think it ain't gonna happen.
But i'm sure a nice implementation of Unreal Engine 3 will be made for wii, because it would just be illogical not to, considering the current and predicted install base and that many games are going to use UE 3

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