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Off the top of my head:

Starcraft & Starcraft: Brood War (has really good voice acting too)

Legend of Zelda: Majora's Mask - very cool that they took a series that had one of the most formulaic storylines of all and created something completely different for this game.

A lot of stuff in the point-and-click genre, like Day of the Tentacle, Beneath a Steel Sky, The Dig.