I do not believe in a new Zelda or Mario in 2009. Usually Nintendo announced such a huge game more than a year in advance to its release. I´d think about Wii play 2, Wii fit 2, Kid Icarus, Mario Party, Pikmin 3 (which has already been announced), a new Donkey Kong or a new franchise. I expect a new F-Zero or Pilotwings as well, but they´re no major holiday titles for me as F Zero sales on the N64 and GC were not that huge.
edit: After last year´s "flop" Wii music they´ll probably think carefully about what they´ll release as major holiday title.







