BMaker11 on 11 February 2009
Snake wins.
Even given Khuutra's "face to face" situation, one second Chief could be looking Snake in the eye, and the next second, Snake is gone. Chief wouldn't be able to find him, and Snake would just crunk his neck.
And, as shown by that video of when Snake first meets Big Mama, you can't just run up on Snake with a gun, even if you have multiple people.
So both scenarios, straight up fight or looking eye to eye, results in Chief getting destroyed by Snake. And I mean, worst come to worst, Snake will throw an EMP, short circuit Chief's suit, and then just slap him around a little bit, before pulling his M1911 and blowing Chief's head away.
