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brute said:
I say the Wii sport series(Wii Sports Japan + Wii Fit + Wii Sports: Resort).
But Call of Duty also has a big shot, also in the Call of duty franchise are you also counting Call of Duty 2 and 3 in the totals?

Yes, I count all of them.

 

I wouldn't dismiss the Brain Series though... If another game comes out (in the Big Brain series) the series could pass 60M for this gen.

 

For a comparison, the best selling franchises last gen were

Grand Theft Auto - 51.92M

Pokemon - 40.34M

Total Mario - 57.09M



http://www.vgchartz.com/games/userreviewdisp.php?id=261

That is VGChartz LONGEST review. And it's NOT Cute Kitten DS