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Put it this way, considering neither of them have any online multiplayer AND both are fantastic games, get the cheaper one first and wait for the other one to drop to that price.

In otherwords, go with Mass Effect (Though I believe Bioshock is the better experience, but I still really enjoyed ME).

Be warned though, you will HATE playing as the Soldier class if you're a FPS buff, I found the controls incredibly frustrating, I recommend picking a class that's not just about firearms (i.e Any class other than Soldier).