Oh I dunno, maybe StarCraft II, but then again, some may knock it down for only containing the Terran campaign.
Bioshock 2 could surprise some, since it's already an established franchise. However, being established is a double edged sword, so it can't rely too much on what made the first one great.
RE5 will most likely get great reviews, but I doubt that it will get them in the same manner as its predecessor. RE4 blew minds and expectations, but 5 is following in its same steps. It's kind of like how MP3 has a lower score than the first. It may be bigger and better, but it didn't revolutionize how the game was played.
At least, that's my two cents...








