@Riachu
they do it through the characteristics of the side characters (such as allergies and people they get along with), through voice acting that actually gives you a feel for what type of person the side character is, by making sure no two look alike, and finally by giving you a bit of the background for each one.
Honestly I think it is mainly the voice acting and visuals that do wonders to give each character a personality of their own.
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