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Real Time Strategy, MMO, Point & Click Adventures and Simulations (building, space, life, any kind of vehicles) are still the genres that are very strong on PC and very weak or non-existant on consoles.

The two bestselling PC games of 2009 are not hard to guess: Starcraft 2 and The Sims 3, but they are not "Killer Apps". They might attract new PC gamers, though.

"Killer apps" don't exist on established systems, this term only applies to games that sell new systems (Wii Sports, Brain Training and Nintendogs were the last "killer apps" I can think of).