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My two personal favourite Pokemon killers.

Weavile w/ Focus sash
-Ice Punch
-Night Slash
-Brick Break
-Aerial Ace

Gengar w/ Scope lens
-Hypnosis
-Shadow Ball
-Thunderbolt
-Focus Blast

Both of these Pokemon will most likely get the first strike in and they can take out most Pokemon with at least one or two hits. With Focus sash you can almost guarantee Weavile gets two hits in and Gengars Scope lens guarantees a better success rate to get a Hypnosis in before your opponent can react.