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Of course this will hurt sales of both titles, but not by a whole lot. RE5 will also be on 360 so should be fine anyway.
Actually I think Killzone 2 will steal a lot of RE5 PS3 sales, because it's a must have PS3 title. This could reinforce the idea that multiplat titles sell more on 360 though, but I think Killzone shouldn't see too much damage.