This gen:
1) Portal
2) TF2
3) HL2
4) MP3: Corruption
5) Galaxy
All time:
1) Half-Life
2)Tie between Deus Ex and Thief 2: The Metal Age
3) Warcraft 2
4) Diablo II
5) Unreal Tournament 2004
Honorable Mentions:
Commander Keen, Prince of Persia, Starcraft, Smash Bros. (whichever one), Mario Kart (whichever one), World of Wacraft, Golden Sun (and The Lost Age), Metroid Prime, Super Mario, Battle City, Sonic 3, Alien Soldier.
Tag(thx fkusumot) - "Yet again I completely fail to see your point..."
HD vs Wii, PC vs HD: http://www.vgchartz.com/forum/thread.php?id=93374
Why Regenerating Health is a crap game mechanic: http://gamrconnect.vgchartz.com/post.php?id=3986420
gamrReview's broken review scores: http://gamrconnect.vgchartz.com/post.php?id=4170835