I'm pretty sure the Wii can handle many NPCs

[SaviorX]

The Wii is stronger than the GameCube right? (Right.)

So if the Gamecube could handle this: http://www.youtube.com/watch?v=VG0ZicLI40g&feature=related

(Go about 2:00 into the video)

and this: http://www.youtube.com/watch?v=dl_YHaQTrPI (Legend of Zelda Twilight Princess:Scaring People of Town)

I think the Wii can handle several more. Maybe Dead Rising: Chop Till You Drop shows the limit, although I hope not. The NPCs obviously aren't important, but for the sake of argument......