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But if Nicole was an illusion the entire time, how would it be possible for her to open doors and push buttons for Isaac? After the beginning of chapter 12, she just disappears and probably just went back into the shuttle/ship. The player and Isaac kinda forgets about that because Kendra showed the full clip of Nicole injecting herself with something (which could be a lethal injection... OR possibly something else), thus making him think that she has died and he was just imagining things.

Other than that, we also can clearly see that Nicole did not look like any other Necromorph, which could also mean that she might not react or act like other Necromorphs.

Nicole was exactly where Isaac left her, and when he returned to the shuttle, it makes sense that she would still be there... and she was.