I've got to say, I think MKWii and Wii Fit are going to be toward the top.
Predictions for 2009: (Right) (Wrong) (Partial)
Pokemon Gold/Silver DS Japan in September
NES colored Wii and SNES Classic Controler for Christmas
Super Role Bros for Christmas
FF Remakes announced; VII PS3 VIII 360 IX Wii
New Super Mario World November 2009