it would result in 10,000 posts saying "i'm no longer going to play games", oddly enough the posters will continue contributing to the site after saying that
more seriously, i don't know what you mean.. if they got the GTA franchise, and were to continue the franchise as is? they'd probably remove the swearing/drug references.. i'm not as creative as a game designer, let alone as innovating, so i wouldn't have a clue on how they'd fix (or simply change) the formula...
as far as aesthetics... i would not expect other Nintendo IPs to infiltrate the main game, and that includes using miis as civilians/players... however i would expect to see random posters with Nintendo IPs plastered onto them every now and then throughout the game