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@ Soriku
The buttons are not very practically placed.  A and B are fine.  But 1, 2 are placed out of whack, and Plus and minus are for start and select.  and home is useless.  So we're stuck with A, B, C, and Z, that are viable and in quick use.  It is theoretically impossible to have your hand comfortably over the a, and forefinger on the b but be able to reach your thumb down to 1, and especially two without it not hurting.  I have huge hands and can barely touch one.
OT:
RE5 could come to Wii, but I hope that they'd tweak the RE engine after RE4 and Dead Rising.  It will definitely be showing it's age in a year or so.