I prefer Kotaku because they seem a little less sarcastic than Joystiq. In all honesty they're all a little mean spirited sometimes but it pisses you off more when they attack your console of choice. I discovered a new one via this website the other day.
http://news.filefront.com/
It's not as fast at bringing the news as the others, but it seems less objective.
Destructoid is new for me. I had heard about them but never bothered to check them out. They're by far the weirdest. As the cofounder says, they're the uncle that tells you dirty jokes.







