The spike protein of animal circulating SARS-CoV-2 is very conserved except for a few adaptive mutations, so I doubt any spillover could happen in the short to mid term.

People's antibody levels to the spike are just too high, so high it likely puts a damper on the emergence of any other Sarbecovirus (sars, etc.) in human populations for decades if not forever (of course, though, human lineages mutating especifically to escape conserved antibody sites will continue to exist).

(Everyone - I've decided to post this here, rather than create a new thread, as I would hate to lose the tremendous history here.  As the last post here is over a year old, I consider this post to be the start of a new pivot for this thread and is based on info I've compiled over the last week.)

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A week ago I stumbled on a press release that goes like this:

EcoHealth Alliance President Peter Daszak to Appear for a Public Hearing Before the Congressional Coronovirus Subcommitee on May 1, 2024

 https://oversight.house.gov/release/ecohealth-alliance-president-peter-daszak-to-appear-for-public-hearing/

I remembered his name from two sources: The 60 Minutes story "What Happened in Wuhan" from 3/28/21

https://www.cbsnews.com/news/covid-19-wuhan-origins-60-minutes-2021-03-28/

Which includes interviews with Daszak and Jamie Metzl (more on him later).

The 2nd source was an article from 5/2/21, written by Nicolas Wade (more on him later), former science editor for the NY Times.

https://nicholaswade.medium.com/origin-of-covid-following-the-clues-6f03564c038

Great article, long read, but worth it. He mentions Daszak on many occasions. After reading this article, in fact, I became convinced that the origin of Covid-19 (C19) was from a lab leak in Wuhan, China.

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Later,  I went back to the Daszak press release and did a search on DEFUSE and found this:

Daszak proposal: https://www.documentcloud.org/documents/21066966-defuse-proposal

DARPA rejection: https://assets.ctfassets.net/syq3snmxclc9/5OjsrkkXHfuHps6Lek1MO0/5e7a0d86d5d67e8d153555400d9dcd17/defuse-project-rejection-by-darpa.pdf

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Next, I found this article dated 3/28/23:

COVID Origins Hearing Wrap Up: Facts, Science, Evidence Point to a Wuhan Lab Leak

https://oversight.house.gov/release/covid-origins-hearing-wrap-up-facts-science-evidence-point-to-a-wuhan-lab-leak%EF%BF%BC/

I instantly recognized the names of the 3 witnesses: Jamie Metzl, Nicolas Wade, and Robert Redfield, former director of the CDC.

Here's Ecohealth trying to discredit their testimony: https://www.ecohealthalliance.org/2023/03/ecohealth-alliance-statement-correcting-inaccuracies-in-testimony-to-be-delivered-before-the-house-select-committee

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On 4/25 - I found this: Fauci agrees to testify in Congress on covid origins, pandemic policies on June 3, 2024

Article connecting Daszak to Fauci: https://nypost.com/2024/04/19/us-news/ex-fauci-adviser-shared-confidential-nih-info-with-ecohealth-about-covid-biosafety-levels-docs/

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Then I found this article, from 4/19/24 which, after thinking about it, SHOCKED ME, in relation to all the prior evidence I've collected, and time spent   connecting-the-dots:

FBI found it ‘alarming’ that Fauci-funded virus research at Wuhan lab would leave no trace of ‘human manipulation’

https://nypost.com/2024/04/19/us-news/fbi-got-tip-that-fauci-funded-virus-research-at-wuhan-lab-would-leave-no-trace-of-human-manipulation/

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Lastly, yesterday I found this:

Hearing Advisory: EcoHealth Alliance President Dr. Peter Daszak to Testify on May 1 - United States House Committee on Oversight and Accountability

I found this sentence of interest: "Prior to Dr. Daszak’s public testimony, the Select Subcommittee will release the full transcript from Dr. Daszak’s transcribed interview* and publish a detailed report about EcoHealth’s impact on the origins of COVID-19."

*from a Nov. 14, 2023 closed door hearing.

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Conclusion:

 I believe the virus we call Covid-19, originated in the WIV lab in Wuhan, China. In fact, it was created by them using Gain of Function (GoF) techniques.

Scientists have known all along that C19 didn't go directly from bats to humans, so there has to be an intermediary host.  Yet, after testing more than 80,000 animals, none of them are connected to C19. If you believe in the lab leak theory, then identifying the intermediary host is easy: laboratory, humanized mice (in this case - mice that have been injected with human cells to give them "humanized lungs").  In fact, Daszak's DARPA proposal spells this out exactly (pg.5, par 2, bottom - "inoculated into humanized mice").

Also, Daszak came up with the idea to conduct this research, and he proposed it to DARPA. Why DARPA?

They are the R&D arm of the US Dept. of Defense. Did Daszak consider his proposal something that could result in the creation of a bio-weapon that would be of interest to DARPA?  Who knows, because DARPA rejected his proposal for many reasons, especially that such work was too risky.

So, what did Daszak do? Did he give up on his idea? NO!  In his DARPA proposal, the WIV was going to do the easy work, and a lab at the University of North Carolina was going to do the GoF work.

Now, with his proposal rejected, he gave all the work to the WIV, and saved money vs. having much of the work done in the US.  Furthur, if the GoF work had been done in the US, it would have to be in a Bio-Safety Level 3 lab.  But in China, they allow such work to be done at BSL-2 - which is what your average dentist office has for bio-safety.

So how did C19 go from a humanized mouse to infect a lab worker? That's easy too. You see, even though they have tiny mouths and noses, they still cough and sneeze like the rest of us. If a lab worker, in a BSL-2 environment was close enough to that mouse when it coughed/sneezed, then it's no surprise that the worker would now be infected with C19.

Also, since a virus created according to Daszak's propoal would have no traces of human manipulation - it could be defined as a potential bio-weapon - an untraceable one at that. One which would appear to have come from natural origins!

Imagine, for instance, that China was involved in a future conflict in which it was losing or had reached a stalemate. They could negotiate for a temporary cease fire - at which time the two sides would be separated by much more than 6'. Then China could introduce the virus on the enemy's side, while it immunized its troops with a secretly developed vaccine - that was in hidden storage. Once the cease fire ended, and as the virus ravaged the enemy, the vaccinated Chinese troops would be free to dominate the battlefield.

History will long remember what took place in the Spring of 2024. When, in the span of one month, the world was witness to the public humiliation of the USA's three biggest adversaries:

1. 1. Iran      2. Russia   (and coming May 1)  3. China

What a stunning and unexpected development.

USATriplePlay                     #USATriplePlay

TheUSATriplePlay                #TheUSATriplePlay

TheUSA-a-TriplePlay            #TheUSA-a-TriplePlay

tba

Are people pushing the lab leak theory again?

https://www.latimes.com/business/story/2023-06-26/u-s-government-debunks-covid-lab-leak-conspiracy-theory-enraging-conspiracy-theorists

The long-awaited report released Friday by the Office of the Director of National Intelligence put the lie to the theory that the SARS-CoV-2 virus, which causes COVID-19, leaked from a virology lab in Wuhan, China, where the disease was first detected in humans.

https://www.dni.gov/files/ODNI/documents/assessments/Report-on-Potential-Links-Between-the-Wuhan-Institute-of-Virology-and-the-Origins-of-COVID-19-20230623.pdf


https://www.webmd.com/covid/coronavirus-history

The latest intelligence reports agree that the SARS-CoV-2 is not genetically engineered or developed as a biological weapon. They do say it is possible a version of a coronavirus was being studied with animals in a lab and exposure occurred there. Again, there is not enough evidence for a definitive conclusion.

Because the first cases of COVID-19 appeared in China, there has been a lot of anti-Asian speech and acts around the origins of SARS-CoV-2


It's always the timing that is suspicious, why now again.


But yes it could have happened from exposure while studying the virus, it has not been ruled out and an intermediary species has not been confirmed. The Pangolin was a good candidate but didn't fit in the end.

However it's not a genetically engineered bio weapon. It's not very effective at it, killing mostly elderly people and those with co morbidities. It hardly effected healthy younger people, those serving in armies... Standing 6' apart also does nothing for an airborne virus. That was all security theater without better ventilation. Same as masks only were 10% effective. Lock downs worked.

The theory that the research was done to get ahead of new out breaks is far more likely. Bio-weapons that attack your own as well, the whole world, who benefits from that? The only ones that benefited from the pandemic where pharmaceutical companies.



And not sure why you would call it humiliation of China, from your own linked article. If it was leaked from the lab, it was from research funded by the USA. Conveniently done in China, far away...

Because, by a strange twist in the story, her [Dr. Zheng-li Shi] work was funded by the National Institute of Allergy and Infectious Diseases (NIAID), a part of the U.S. National Institutes of Health (NIH). And grant proposals that funded her work, which are a matter of public record, specify exactly what she planned to do with the money.

The grants were assigned to the prime contractor, Dr. Daszak of the EcoHealth Alliance, who subcontracted them to Dr. Shi. Here are extracts from the grants for fiscal years 2018 and 2019. “CoV” stands for coronavirus and “S protein” refers to the virus’s spike protein.

“Test predictions of CoV inter-species transmission. Predictive models of host range (i.e. emergence potential) will be tested experimentally using reverse genetics, pseudovirus and receptor binding assays, and virus infection experiments across a range of cell cultures from different species and humanized mice.”

“We will use S protein sequence data, infectious clone technology, in vitro and in vivo infection experiments and analysis of receptor binding to test the hypothesis that % divergence thresholds in S protein sequences predict spillover potential.”

What this means, in non-technical language, is that Dr. Shi set out to create novel coronaviruses with the highest possible infectivity for human cells. Her plan was to take genes that coded for spike proteins possessing a variety of measured affinities for human cells, ranging from high to low. She would insert these spike genes one by one into the backbone of a number of viral genomes (“reverse genetics” and “infectious clone technology”), creating a series of chimeric viruses. These chimeric viruses would then be tested for their ability to attack human cell cultures (“in vitro”) and humanized mice (“in vivo”). And this information would help predict the likelihood of “spillover,” the jump of a coronavirus from bats to people.

The USA knew what she was doing and funded the research.

If anything it's more humiliation for the USA. Exporting dangerous research to a cheaper location.