TA: Spring is one of the better ones around, basically Supreme Commander (it is actually based on Total Annihilation hench 'TA') but with more basic graphics, however it is a much more slick experience. It has however recently been made a lot more complicated in setting it up as you need to download the spring engine (almost like a client) then a multitude of other things to get it working, it used to just be a single .exe, but once it is up its smooth sailing from there and it has a very robust online component.
Homeworld 2 is just about the best real time space rts of all time.
Sword of the stars, probably the very best turn based strategy of all, and that includes games such as Galactic/Civilisation and Space Empire.
I could suggest others but to be honest you can't go wrong with those three. The good thing is that in a week or so the steam post christmas/january sales should make many games stupidly cheap.