I will conceed that because you are absolutely right.  However, without this game its very possible we would never have gotten some of the other great (and maybe underappreciated/low selling) strat RPGs such as Disgaea, Jean D'Arc and others.  Like the OP said with Tower defense games, there have been so many (good and maybe bad) that the original that brought them into the limelight has been overlooked.  Just saying with FFT, this has not happened.

Oh yea, Quake started the hugely successful play-online FPS.

It succesfully reinvented the Metroid frachise, which was unique in its own right, in full 3D. It was not a FPS, but a FP Adventure, and the first one to do it utterly right. Just read any of the reviews from when it came out, people were stunned. I remember it fondly. :)

We're talking about games that changed the industry, not reinvented themselves. Look at the OP. There was no rippling effect caused by the existence of Metroid Prime. The closest games to it are Bioshock and Condemned, and both could have and probably are as inspired by System Shock and Half-Life as they are to Metroid Prime.

The following games I mentioned were sequels:

* Grand Theft Auto 3 (put sandbox games on the map).

It was the third game in the series, but the first to go 3D route, with the use of cut-scenes, and put sandbox on the map.  The two prior ones were 2D, and over the top, and didn't have missions to them.

* Final Fantasy VII (add FMV to JRPGs)

Sounds a bit ironic here, but this did put the FMV cut scene on the map.  Anyone here want to argue that Final Fantasy VII was not game changing in what it did and sales?

* Madden Football (EA finally put football on the map with this on the Genesis)

First series to do full 11 on 11 American football in a meaningful way.

* Street Fighter II

This was the first to follow the model for one on one fighting games.

one problem I see with your list is that most if not all of them weren't game changers they just popularised older changes.

* Super Mario Bros. = ok I will give you that

* Tetris = that to

* Grand Theft Auto 3 (put sandbox games on the map). = yes but sandbox games were around long before even the first GTA wasn't the first sandbox

* Final Fantasy VII (add FMV to JRPGs) = FMVs yea they were around before FF7

* Madden Football (EA finally put football on the map with this on the Genesis) = OK

* Street Fighter II = not the first but it was popular

* Gran Turismo (driving sim done to that scope) = Ok that was kinda revolutionary

* Wii Sports (I will throw this on here due to motion control, rather than just controller) = well it was a thech demo I don't realy think it as a game changed anything why don't you just replace it with the Wii

* Legend of Zelda = ok

* Guitar Heroes/Dance Dance Revolution. DDR i will give you but Guitar hero wasn't even the first Guitar rhythm game

* World of Warcraft (breakthrough title for massive multiplayer RPG) = replace with EverQuest

* Starcraft (definitative RTS, that became a phenomenon in South Korea). = but it was just a refined and upgraded Warcraft 2 which was the same for Warcraft 1 and Dune 2 was the real game changer

* Nintendogs (put pet simulator on the map in a way that generated sales) = once again just popularised it

* Brain Age (put doing puzzles/brain development, is put on the map) = popuralised

* Wii Fit (fitness becomes a game). = wasn't the first

so basically from your list you wan't to know when today's innovations will catch on? well I don't really see anything new but MAG may popularise large scale online FPS games poor Battlefield.

another point I hate it when people act like user generated content was invented by littleBigPlanet Blizzard RTSs for one have been doing it for years in my opinon its one of the better inovations they made to the RTS genre. User generated content is an old concept and as far as I know there are much better implementations.

The interface and hud alone were copied by multiple games after Prime 1. And I think being the first succesful First Person Adventure is worth a mention too, it's not just that it re-imagined the whole Metroid experience itself, it's that the elements it used in doing so were applied to other games as well. It's not just games like Bioshock, there are far more, such as the Star Wars Republic Commando games, and even Mirror's Edge, to a certain degree. Okay, so Metroid Prime may not have had as much influence as, say, Wii Fit, but to dismiss it altogether is just wrong.

Just look at this and tell me with a straight face it's not at the very least 'influenced' by Metroid Prime. With a screenshot of Prime 1 to the right, for comparison. :p

My videogame playing goes back to Atari 2600 days, and arcades back in that day (you SERIOUSLY told someone who owns and played Pocket Kingdom on the N-Gage to play more games?  If my collection here isn't weird enough, I will need to add more)).  If you want to ding me on anything, I would suggest you ding me on coming up with very poor examples for a point I was trying to make.  My original post was somewhat poorly formed, trying to mash together multiple ideas, and it not working as well.

The concepts:

1. Have we hit the end of the line as far as a single title coming along that is not a large derivative of other game genres, that will dominate the videogame arena, that is also exclusive, so that it ends up being the "killer app" of a give videogame generation but also be new?  So, it isn't just a case of being original, but selling a TON of sales of the game, and being something that causes someone to buy one console over another one.

2. Will any new genres appear and become popular, that aren't heavily derived from other game genres?

2a. Are we at the end of new game genres appears?

2b. If we aren't at the end of new game genres appearing, then will the new genres come about by means of revolution or evolution?

So, I wasn't just looking innovation here.  I was considering also sales and popularity factor.