My top twenty games in rough order based on my ps3 and Wii collections:
1. Twilight Princess
2. LittleBigPlanet
3. Okami
4. Uncharted 2
5. Demon's Souls (this may switch with Uncharted 2 over time)
6. Metal Gear Solid 4
7. Mario kart Wii
8. Uncharted
9. Super Smash Bros. Brawl (this one just didn't stick with me like Melee)
10. Super Mario Galaxy (I think it may be the locales, but I wasn't captivated by this like I was SM64 and SMS)
11. Killzone 2
12. Ratchet & Clank Future: Tools of Destruction (and Quest for Booty, which is imo even better)
13. Flower
14. Little King's Story
15. Street Fighter IV
16. Heavenly Sword
17. Valkyria Chronicles (lost my save file 60% through - may never go back =()
18. Super Paper Mario (I absolutely love the style of this game, but I can't seem to get around to finishing it)
19. Armored Core: For Answer
20. Infamous (lost my save file 50% of the way through - don't care to go back =/)
At the bottom there I was kinda reaching for stuff to add, but as you can see, ps3 has my favor by a decent bit.
This list also shows why Nintendo and Sony are easily my two favorite publishers. Just about everything they develop internally is gonna be awesome, and most of the stuff they publish turns out pretty darn good as well (the exception being Lair).
Keep in mind I ignored handhelds because I rarely play those, and I ignored any titles I generally play on PC (L4D, CoD, SupCom, other RTS games). I also left off the Gears titles. I've loved what I've played, but haven't played enough to make a definitive statement about where they deserve to be placed.