Here's what I'd like. I want an open world Raccoon City circa Resident Evil 2, which means the city is blockaded by police to give it a natural cut off point. There can be different blockades that get broken down by zombies later on to allow you access to more areas of the game. The game will take a more natural approach to a city infested with zombies, so there will be people in the game AI controlled in single player, or player controlled in co-op that you can join up with, or you can go it solo, your choice.
Now Resident Evil has never been very good at the horror aspect. It was good for it's time, but the earlier games today are no more scarier than the newest one is. Within three years, Silent Hill had shown up every Resident Evil in existence in the horror aspect. To fix this, the new game applies a few new tricks. Every building you can go in does not load. There is no loading during the opening of doors. All window can be shattered like in RE4. The scare tactics in the game will be random. One person can get a scare in a long hallway at the police station with crows flying through the window and another person can simply walk through and nothing happens. Enemy locations and numbers will also be more randomized. You will use a flashlight and employ the RE5 cave trick of complete blackness sometimes.
There will be many more opportunities to hole up in a building and have the Night of the Livind Dead/RE4 house scenario where you have to defend an onslaught of zombies trying to invade a building.
As far as the storyline goes, basically re-do it. Let people have different characters each with their own goals, and you can assist someone with theirs and they can assist with yours. Let's say you have Jill Valentine and her goal is to escape Raccoon City and you meet up with Leon Kennedy, who's goal is to find Claire Redfield. You two can join up and now have two different scenarios. If you bore of tagging up, you can branch off and choose either character, no matter which one you started with. Allow a total of four playable characters in the game, each with their own story. Maybe Jill Valentine, Chris Redfield, Leon Kennedy, and Claire Redfield. Actually maybe some real different types of characters, like Albert Wesker, Barry Burton, Chief Irons and Annette Birkin.