I'd be surprised if Uncharted 2 didn't outperform Killzone 2.
Uncharted was popular on PS3, even allowing for bundling, and with the addition of MP plus Coop, an apparently even longer, bigger and better SP campaign plus even sweeter environments and gameplay, so I find it hard to believe most people who have a copy of Uncharted wouldn't pick up the next installment.
Killzone 2 was of course released on the back of good sales for Killzone, but it was the first in the franchise on PS3, and of course Killzone had a more lukewarm critical reception than Uncharted, so I think Uncharted 2 has all the ingredients to do very well.
If it doesn't open strongly then I'll just be flat out astonished and unsure what titles PS3 owner's actually want.