Decided to take a tally of the games named here. (Up to Boutros)
Showed:
No More Heroes is the most popular "niche" Mature title on Wii, most closely followed by MadWorld
The Conduit already beats World at War and Heroes 2 in the FPS category.
Umbrella Chronicles narrowly beats Overkill for on rails shooter.
Mario Strikers Charged beats Pro Evolution Soccer.
And the top is a laundry list of Nintendo franchises: Galaxy, Brawl, Twilight Princess, MK, Metroid Prime 3.
Here are the titles with 10 or more mentions:
Super Mario Galaxy – 42
Super Smash Bros Brawl – 41
Legend of Zelda: Twilight Princess – 40
Resident Evil 4 – 35
Mario Kart Wii – 34
Metroid Prime 3 – 31
Wii Sports – 28
No More Heroes – 23
Super Paper Mario – 22
Zack and Wiki – 22
The Conduit – 19
Okami – 19
Resident Evil: Umbrella Chronicles – 16
MadWorld – 15
Mario Strikers Charged – 15
House of the Dead: Overkill – 15
Wii Fit – 15
Boom Blox – 14
Fire Emblem – 14
deBlob – 13
Call of Duty: World at War – 12
Wii Play – 11
Little King’s Story – 11
ExciteTruck – 11
Punch-Out – 10