I vote for fallout 3.

Havent play F3 yet but Mass Effect sure was the most epic, but i actually had more fun with Fable 2.. Both titles are impressive. So i dont know.

Mass Effect, so easily...

now list your reasons why?

I have played none of them but Fable 1 was really great, I've seen a little of Mass Effect and it looked awesome and Fallout 3 looked boring so...I will vote for Mass Effect. lol

Story and characters, of course. Bioware's work is always extremely deep, and this is no exception.

None of them...

Oblivion Wins hands down.

for me fallout 3. The biggest world map I seen alot of intersting weapons. and most definte the setting. Post nuclear wasteland. FALLOUT FTW.

If you think a bunch of sci-fi cliches is a deep story, then yes.

But still... writing is solid. So among them - Mass Effect.

Fallout 3-beautifully realized world with believable characters and a great VATS system with plenty to do besides the main story.