Fallout 3 -Love your parents

Oddworld -Keep your friends close

Final Fantasy VII -Never give up hope

Indigo Prophecy -Become a serial killer, let the world go to hell, and you'll get laid (lol)

The Sims- Life is nothing but a tedious succesion of monotonous, grinding, endlessly repetitive daily tasks.

Phoenix Wright- If you have a badass lawyer, everything turns out alright. Also, they're called stepladders.

Baldur's Gate- GO FOR THE EYES

KotoR- Amnesia can be a bitch

Tekken- Dragon Uppercuts fuck shit up

Harvest Moon- Picking up random multicolored grass is actually a viable source of income

Mario Kart Wii - (Cross Country) races are never over until the very end
Roller Coaster Tycoon - Fun and games is not all fun and games
Super Mario Galaxy - Universe = AWESOME!

Street fighter- When you get knocked out you go ""OH AH OH AH OH AH""

Then you get told to go home and be a family man.

no more heroes: it is possible for a man to live only of pizza, his cat and porn.

Also

Mortal Kombat (original) -If you suck, a narrator will tell you that you suck

Grand theft auto china town wars- When busted by the police for trafficking heroin, they'll just release you straight away.

Dead Space - shit happens

Left 4 Dead - even when the world is F***ed you can still joke about it

Dead or Alive 4- Apparently its completely normal in Vegas to watch a Ninja fight a pro wrestler in the middle of the road, with oncoming traffic.

Any FPS - You can be hit by many bullets, but if you duck behind a rock or a wall and wait a few seconds you will heal and can take many more bullets.