System Shock 3
World of Goo 2

another 2d entry in the secret of mana series

another 2d chrono game

legend of dragoon sequel

a good ghostbusters game

a 2d zelda that is similair to links awakening/link to the past (the good zelda games)

original deus ex styled addition to the deus ex series

a new made by naughty dog crash game

a new made by insomniac spyro game

a loaded remake

the baby of a threesome involving motorstorm, wipeout, and hydro thunder

a sequel to valkyrie chronicles

new battletoads

I'll stop here as I could go on forever

Shenmue III
Jet Set Radio 3
Sonic Adventure 3 (assuming similar quality to the previous two)
Conker 2
Phantasy Star V
Lost Odyssey 2
Kameo 2

Oooh, I like the Pokemon TCG idea.

Mario and Sonic: Platforming Game of the Forever
Sonic Adventure 3
The Legend of Zelda - A Link to the Future
Fire Emblem XI - M
Super Mario RPG2 (possibly with Sonic?)
Paper Mario DS
Super Smash Brothers DS
100 Classic Book Collection - 2

Should I be disappointed that almost every suggestion thus far is either a sequel or a port? Or is that just to be expected, realistically?

Back on topic, another neat thing I'd like to see is a game which uses the Wii Wheel unconventionally. How exactly I'm not sure, but then, I'm not the one with the game development budget anyway.

^^
Maybe use the wii wheel like a frisbee?

^ We love our good ol' series (when some of them didn't go bad). :(

Goldeneye 2 does exist. Remember Rogue Agent?

*shudders*

A frisbee is an interesting idea. Another is to make the Wii Wheel into a sort of player-held avatar of the in-game object they're controlling, and using the tilt, distance, and pointer controls to control that object's position in space. That could be used for pretty much anything from a 3D Marble Madness equivalent to a flight sim where you literally are holding the spacecraft in your hands instead of a control stick for it.

a new Crash Bandicoot platformer or racing.