My personal pick is SSBB, but GTA4 will coast to a victory for most publications/review sites.

I'm going to say if kid icarus is good. Or nintendo put's another zelda in quarter 4. Which is somewhat possible.

I'm hoping Spore comes in and steals it away from the multitude of sequels we're getting this year.

 Reviewers are always bias against pc imo. Especially gametrailers. Last year they gave CoD 4 best graphics award , because their pc couldn't run crysis. So I hope spore comes to all consoles so they could treat it fairly. 

MGS4. If GTA4 wins,.......... I can't even explain in one thread......... MGS4, FTW *whatever that means*

QFT, bump, FTW, TOSKOR, you're killin' me here :/

GTA IV ,according to  reviewers it is the best game since OoT.

Wii fit! ^^

gta4 unless starcraft 2 releases

For me, GOTY is Super Smash Bros. Brawl.

But with all the (ridiculous) love that GTAIV is getting from all the major gaming sites, I don't see them backing off from that game.

I'm also rooting for Spore to be a great game.

Killzone 2 KZ2

Resistance 2 R2

Gears Of War 2 GeOW 2

Metal Gear Solid 4 MGS4

WiiFit

SSBB

my personal pick is goin to be
LBP If it turns out how its supposed to. its so new and fresh
GTAIV most likly tho