Yup. I should try going with more vague hints

#44 Game Description: This sequel follows it's predecessor by having a touch based story mode where you play mini games revolving a specific item to get coins and accessories. It's other mode is a more widely recognized and despite being newer, it can still pair up with any past game on the this system for multiplayer goodness

Game hint: Oversized heads and hands with lots of explosions!

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#42 Game Description: A fighting game that is regarded as the best version, despite having 2 sequels released after it. Is still played widely to this day

Game hint: UWAaaahh!

#43. Professor Layton?

#42. Super Smash Bros. Melee?

#43. Nope

#42. Correct! :D

You were ninja'd but yes :p

44: DW7

43: Crash 2?

42: Star Wars Galaxies?

41: Medieval Total War?

40: Killzone 2?

47: An RTS with castle building mechanics as its main draw. Featured fun ai matches that varied in difficulty by the personalities of the specific enemy ai.
Hint 2: Balance between Food, Weapons, Gold, Resources were very important to manage.

46: 1st game in a platformer trilogy. Goal seems to be to save your family, but you mostly get rich and beat people up.
Hint 2: You set people on fire or poke them with spiky horns.

45: 1st direct sequel to a RTS series that features tanks, teleportation, mind control, and more!
Hint 2: Einstein and alternate history timelines make appearances.

44: Warriors game that introduced a quick fodder killing mechanic for even more ludicrous mass killings.

43: Open World game set in a modern asian city.

Waiting for you to post so I can feel less awkward about reposting my spam.

Now I can answer some hints myself :P.

I would be surprised if 41 was actually Bladestorm though. Surely there are more that I am missing eh.

Yes to all, but I forgot to specify between Stronghold and Stronghold Crusaders. Close enough though.

Speaking of Crusaders. Crusader Kings 2 I am guessing.

At last! I was about to give up!

By the way, I think nobody has guessed my #41:

 # 41: This game belong to a series with many spin-offs, one of which, certainly the most successful one, was launched the year which appears in this game title.

Additional hint: This game was ported to many platforms, including PSX and N64. N64 received an exclusive game of the series, but it only worked with certain peripheral...

Edit: Since here in Europe is day #41, I'm going with my #40 hint:

#40: Last entry of a series that in Japan and the West is known by the name of the first console were the series was released (in each territory). Of course the name of the series is different in Japan and in the West. Also, the name of this particular entry is different in NCTS and PAL territories.

43 – Sid Meier’s Civilization III

Civilization III was my first “empire management” game. After playing several RTS games, focused on resource gathering and military command, I dreamed with a game that would let me to control every aspect of a country. This desire would be later fulfilled with the 5^th game on this list but, before that, Civ III was a huge step in that direction. For the first time in my life, I could feel like the real governor of a country, deciding how to enhance my Empire, where to found a new city, what infrastructures should my country have and declare war or signing peace.