There's been a few times where enemies have either glitched or gotten stuck in the evironment, allowing me to easily attack them with no threat of retaliation.  One example of this was in Fallout NV where there's a ton of deathclaws at the quarry including an alpha male AND a queen / mother death claw.  Took me a ton of ties to take them both down along with their brood, and I was only finally able to by climbing on top of one of the cranes where they would get caught in and endlessy cycle of trying to reach me and then targeting my companion instead.

Also completing the prototype speedway race in Forza 4... for some reason no matter how I tuned my cars the CPUs were always faster and controlled like they were on rails, but finally on one race attempt the two lead cars took each other out, and I was able to stay ahead of the pack for the remainder of the race, otherwise there was no way in hell I was gonna win.

There was some special item in there if I remember right. The place they are found is near water. I recall luring them one by one to control their numbers and then going for the big ones. It took me a lot of tries but it was worth it. :D

Tagged.

Yeah one of the side quests required you to collect 3 deathclaw eggs, which could only be found in that area.  I think there was a Fat Man and some other powerful weapons / ammo to be looted in the area too.