I'll go with these in no particular order...

Wii Sports, Trauma Center, The World Ends With You, Rune Factory and Elete Beat Agents/Osu!

1. Valkyria Chronicle

2. Last of Us

3. Uncharted

4. Heavy Rain

5. Mass Effect

1- The Kyle Hyde Series
2- Xenoblade Chronicles
3- Radiant Historia
4- The Professor Layton Series
5- The World Ends With You

Rune Factory!
TWEWY
Radiant Historia

Didn't like Etrian Odyssey a lot till Untold, but I definitely liked the original (Especially 2)
Xenoblade? (Not sure if I can say this, since I really like Xenoblade X, but did not play the original yet)

1. Uncharted
2. Bioshock
3. Last of Us
4. Borderlands
5. Assassin's Creed

Looking back, last gen was amazing for new IPs. So many good ones.

Skate
Pursuit Force
Heavenly Sword
Uncharted
Minecraft

(in no order)

Mass Effect

Assassin's Creed

Mario Galaxy

Gears of War

Bioshock

1, Ni No Kuni
2. The Last of Us
3. Uncharted
4. Catherine
5. 3D Dot Game Heroes

*Honorable Mentions - Batman Arkham & Bayonetta

1. inFAMOUS
2. The Last of Us
3. Hotline Miami
4. ModNation Racers
5. Assassin's Creed

On top of my head, it would be these:

· Dead Rising. It's actually a damn awesome game, with an original story for a zombie game, some daring plot twists and a superb gameplay system (if you can endure the time constrains, but imo that's what gives the game a doze of personality). It spawned three sequels, two main entries and a spin-off. Both the second game and the Off the Record version are damn great as well.

· Dragon's Dogma. One of the best games I've ever played. It's a unique RPG, and there's nothing like it. Its clever, memorable ending stuck with me for some time.

· Demon's/Dark Souls. I'll stump them both together, though I played Dark Souls first. Two truly amazing games with an almost flawless design and incredible replay value, plus satisfying gameplay that keeps you coming back for more. Dark Souls is also one of the best games I've ever played.

· Gears of War. Memorable franchise, and the third game actually made me play multiplayer for a long time, which is actually quite the feat.

Now I'll proceed to name two different games, because I'm not sure the first one qualifies, as it got released cross-gen:

· The Evil Within. Fantastic game with an immersive atmosphere and visceral combat. Plot is weird as heck, and there's a lot of entertaining moments throughout a lenghty campaign.

· Uncharted. While the first one was an interesting, enjoyable affair, the second one was an amazing experience and a fun game altogether, with high replay value and one of the most memorable intros in videogame history. The third one is a bit weak, though, but the fourth one is shaping up to be fantastic.