Strengths
+He's over 7 feet tall with great athleticism and strength. In today's game where there is an obvious lack of quality 7 footers.
+In his prime, he had all the post moves to be efficient in the league: fadeaway jumper, finger roll, drop step, etc.
+He's the only center to ever lead the league in assists, meaning that he's one of the best passing big men of all time.
+He's has never fouled out of a game, despite his physical gifts. This means that he was more of a finesse guy and he plays good defense without fouling.
+Before, there was no such thing as illegal defense so teams would load up 3 guys on him even before he could touch the ball.
Weaknesses
-In today's game, defenses are much more complex and guys are physically stronger and more imposing.
-There are a lot more guys who are the same size as him, unlike the old days.
-Athletic guards and forwards dominate this game now and the speed of the game would probably limit his effectiveness.
-Stretch 5s and 4s would force him to step out of his comfort zone (to the three point line), limiting his rebounding and defensive potential.
If you put those together, I believe Wilt would be someone like Dwight Howard now but with more assists. He'd probably average about 18 points, 12 rebounds, and 8 assists.
He used to score 50 and rebound 25 back then, but that's because there was nobody around that could compete with his size. He can still score since the rules of today favor the offense and he has the size and the shots to create for himself. However, the complexity of defenses have limited the scoring potential of behind the basket big men, and the size and athleticism of forwards and guards running to double team would make him more of a passer, which he was at the end of his career, as the trend started to change to what it is today.