A rule of thumb I would suggest is to think about the big picture of your action. Would lying about something cause even more pain to the person you're lying in the future? To other people?
For example, say a friend is being difficult with your other friends, without being aware of it.
If you tell your friend the situation, that might hurt your friend's feelings, but that could avoid a potential blow up later and save your other friends some pain too. On top of that, you should consider how you actually execute your confrontation will affect things.
Once you've considered those things, follow a utilitarian mindset and do whatever you're going to do.