Well if the control setup is going to be a spiritual and technological heir to that of the Wii remote, then definitely Metal Gear Solid Rising. Also bring on the shooters like Portal 2 and Crysis 2.
But obviously, none of us know where Nintendo is going to go with N6 in terms of control or tech power (although if 3DS is suggesting anything it could be quite a hoss). Also we still don't have any idea when it'll release, although I'd still suspect 2012 being the latest and Holiday 2011 being the earliest. Actually been saying that for quite some time haha so don't call me timely haha.
And hopefully people won't hate me for this, but I really hope that Skyward Sword is pushed back and put on this new system, similar to what happened Twilight Princess. Not that I don't think it is already great and would be on Wii (trust me you would never hear me say the opposite), but would be nice to have another Nintendo system launch with Zelda in the mix.