In October 2010 we're going to see many big games released and so share with the rest of the world which game you think will have the:

A) Highest Reviews (Metacritic wise) and

B) Biggest First Week Sales

or you can just rank them

Here's a list of the big October Games:

Vanquish
Medal of Honor
Enslaved: Odyssey to the West
Castlevenia: Lord of Shadows
Fallout New Vegas
Fable III
Rock Band 3
Star Wars: The Force Unleashed 2
Wii Party
Kirby's Epic Yarn
NBA Jam

If you think I've missed out on some other big games, let me know.

You left out Kirby and NBA Jam

Anyway:

Reviews: Probably either Fable 3 or Fallout; Vanquish could pull a high score

Sales: Rock Band 3, Fable 3, or Fallout. Wii Party and NBA Jam are also solid possibilities

Fable III, New Vegas, and Epic Yarn look to be the biggest potential critical darlings.

As for sales? NBA Jam and Wii Party are wild cards, but could take off in a big way, likewise with New Vegas. Rock Band 3 has the numerical advantage for multiplat-ness, but music games aren't what they used to be in the sales department.

i hope kirby does well i dont have a wii but that game looks cool

meta score..... Vanquish/87
Medal of Honor/83
Enslaved: Odyssey to the West/79
Castlevenia: Lord of Shadows/90
Fallout New Vegas/92
Fable III/91
Rock Band 3/75
Star Wars: The Force Unleashed 2/7
Wii Party/69
Kirby's Epic Yawn/93
NBA Jam/65

i think MOH and fallout will be the big sellers for that month enslaved, RB3 and vanquish will probably have the weakest sales with the rest doing average sales

ps: the score i gave are based on how the game looks and are guesses

Vanquish --------------------------------------- 9.1 on PS360 ----------- 360 - 300k, PS3 - 280k
Medal of Honor ------------------------------ 8.6 on PS360 ----------- 360 - 560k, PS3 - 480k
Enslaved: Odyssey to the West ?
Castlevenia: Lord of Shadows ?
Fallout New Vegas -------------------------- 8.6 on PS360 ---------- 360 - 600k, PS3 - 450k
Fable III ----------------------------------------- 9.1 ----------------------- 1.2 M
Rock Band 3 ----------------------------------- 8.9 PS360Wii
Star Wars: The Force Unleashed 2 ----- 8.7 PS360
Wii Party ---------------------------------------- 7.4?
Kirby's Epic YaRn ----------------------------- 9.4 ---------------------- 350k
NBA Jam ---------------------------------------- 8.5

my rushed predictions!

A) Kirby's Epic Yarn [Not Yawn haha], Fallout New Vegas or Fable 3. [Possibilities in that order]

B) Fable 3.

I expect something like: 

Vanquish 8.5
Medal of Honor 8.0
Fallout New Vegas 9.1
Fable III 8.9
Rock Band 3 8.5
Star Wars: The Force Unleashed 2 8.0
Wii Party 7.5
Kirby's Epic Yarn 9.3
NBA Jam 7.0

Lol at Epic Yawn

Lol sorry for the typo people. It's been fixed to Kirby's Epic YARN :D!

Fallout New Vegas will have the highest rating. It will also have Beasty sales.

1.  Kirby Epic Yarn will score the highest.  The media is frothing over that game (my best guess)

2.  Medal of Honor,Fable 3, and Fall Out in that order (my best guess)