I can't play handhelds moving anyways so I don't know why I would try with the 3DS. I do get motion sickness rather easy, however. 3D in general does make me kinda disoriented (why I won't see 3D movies in theaters) but I'm never sure how much of that is due to the glasses they make you wear. I'm sure there is quite a sizable portion attributed to that. Though I'm sure the 3D without glasses will still cause somewhat of a disorientation given what the 3D effect is doing on your eyes. However, as stated, no need to always play with 3D due to the slider.
I'll go out on a limb and say that those who really aren't messed up too much in 3D movies or by playing handhelds on a system in a moving craft, probably won't have any problems with 3DS in any scenario. Those with motion sickness, probably will want to turn the 3D off or just not play it while moving. Those with issues with 3D probably just won't want to play it under any scenario that might enhance the issue. Me, I'll just hope that a lot of it was due to the glasses although I'm sure I won't have too many issues with it. Of course I'll never play it in a moving vehicle haha.








