At the core, HR is an adventure type game like all those Sierra games from the 80s and early 90s, which themselves were crude animate 2D graphical versions of the text based adventure games that preceded them.
As it's already been mentioned, hand drawn 2D based adventure games still thrive in other markets, but adding the cinematic elements of HR along with its production values makes the end product more appealing to a broader general audience.
Ultimately, it seems that a combination of a compelling story, different game play and good word of mouth have been enough for a successful launch week. I'm curious to see how sales hold up over time or whether it will be heavily traded in.
While it's tough to say the early success of HR is going to result in another resurgence of adventure game titles with emphasis on story, it may be a part of the natural evolution of games in terms of changing expectations and standards for storytelling within fully interactive media.