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Take every game with a male protagonist and imagine the protagonist as female, and then vice versa. Samus being male? Wouldn't change much. There are not that many games where replacing the female protagonist with a male protagonist would make much of a difference. Often times developers just don't understand how to fully flesh out a female main character with the characteristics of the gender.

However, try to replace the male protagonist from several popular games with a female protagonist, and you'll see that it doesn't make much sense.