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Weapons- While I'm sure Resistance will have the cooler weapons, nothing beats a shotgun when blowing a zombies head off. Left4Dead

Enemies- Endless waves of zombies always win. Left4Dead

AI- Well since Resistance is primarily a single player game and Left4Dead is purely multiplayer with only mindless zombies I guess Resistance 2 gets this one.  I know a lot of people are talking about the director, but I don't lump that in with the AI (even though I should), I put it in its own awesome catagory.

Art Direction- Resistance 2, but only because it's hard to make a new interesting zombie art direction. In my opinion they're both pretty boring.

Replay value- Left4Dead

Graphics- Resistance 2

Sales- Left4Dead -- go go Steam

Overall- Left4Dead easily