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I gotta echo most others and go with Hendrix. He taught himself how to play. He couldn't read music. He played a right-handed guitar, left-handed. The man ate lightning and shit thunder.

After him, I'd probably go with:
Satch
Eddie
Steve Vai
Randy Rhodes
Dave Mustaine
too many good ones, really, I could go all night.


For the record, Cliff Burton is the best bass player, imo.
Followed by Steve Harris.
Dave Ellefson gets special mention for my favorite bass line ever in "Peace Sells..."