A Game Unlike Any Other... What Are Some Examples?

[HoloDust]

Bofferbrauer2 said:

The 1996 game DEUS (no relation to Deus Ex) and to a lesser degree, it's predecessor Robinson's Requiem.

1. It's Open-World FPS, where else do you find that?
2. You have 3 pages to check on yourself and to apply some kind of medicine (the game came with a book that explained what you need to do for what kind of injury, poisoning, disease, etc...)
3. Ever saw an FPS with a character catching cold?
4. Needing tranquilizers to get his heartrate down?
5. Overdosing on said tranquilizers for going on too long without resting?
6. Sewing your own clothes to visit colder regions to avoid the aforementioned catching cold (which can get deadly if you go on for too long without treatment)?
7. Being able to amputate parts of your body?
8. Screen turning black if you amputate both eyes? 
9. Needing food and water to survive in an FPS?
10. Needing to rest in an FPS?
11. Having dozens of potential death causes?

https://www.youtube.com/watch?v=LyNIcM2Gqpc

https://www.youtube.com/watch?v=guiEfcTaRV8&t=92s

Oh, that's a blast from the past - I know of this game, but never played it. Though I'd say, although very unique for its time, in last decade or so with so many survival/FPS/RPG games (my younger son's obsession with ARK comes to mind), it probably has a fair amount of (most likely unwitting) successors...at least to a degree (first time I heard about it was back in 2005 when someone compared some of the things Boiling Point: Road to Hell was doing to DEUS).